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Published on: March 12, 2020
Structure guided approaches toward exploiting and manipulating nonribosomal peptide and polyketide biosynthetic
Heather L Condurso1, Steven D Bruner
1Department of Chemistry, University of Florida, Gainesville, FL 32611, United States.
Abstract:
Nonribosomal peptide and polyketide natural products are structurally diverse small molecules synthesized on complex enzyme assemblies. The ability to rationally engineer secondary metabolic pathways is a promising approach to novel therapeutics. Atomic resolution structures of biosynthetic enzymes provide information on active site architecture and macromolecular assembly that can aid in the engineering of new compounds. This review surveys recent applications toward biosynthetic engineering of natural products guided by structural biology.
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