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Phosphorylation prevents C/EBPβ from the calpain-dependent degradation

Yuan-yuan Zhang1, Shu-fen Li, Shu-wen Qian

  • 1Key Laboratory of Molecular Medicine, The Ministry of Education, Department of Biochemistry and Molecular Biology, Fudan University, Shanghai Medical College, PR China.

Biochemical and Biophysical Research Communications
|February 29, 2012
PubMed
Summary

Phosphorylation of CCAAT/enhancer-binding protein beta (C/EBPβ) by specific kinases enhances its stability and DNA binding activity. This dual phosphorylation protects C/EBPβ from degradation, crucial for adipocyte differentiation.

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