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[Clonidine treatment in manic episodes].

S Diacicov1, B Tudorache

  • 1Spitalul Gh. Marinescu, Bucureşti.

Revista De Medicina Interna, Neurologie, Psihiatrie, Neurochirurgie, Dermato-Venerologie. Neurologie, Psihiatrie, Neurochirurgie
|January 1, 1990
PubMed
Summary

Clonidine, an alpha-2-adrenergic agonist, effectively reduced manic symptoms in 65% of patients within ten days. This antihypertensive drug offers a practical advancement in acute manic disorder therapy with excellent tolerance and minimal sedation.

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Area of Science:

  • Psychiatry
  • Pharmacology

Background:

  • Acute manic disorders present significant treatment challenges.
  • Current therapies, like neuroleptics, can have substantial side effects, including over-sedation.
  • Clonidine, an alpha-2-adrenergic agonist, is primarily known for its antihypertensive properties.

Purpose of the Study:

  • To evaluate the efficacy and safety of clonidine in treating acute manic disorders.
  • To assess the speed of onset and duration of clonidine's therapeutic effects.
  • To compare the side effect profile of clonidine with traditional neuroleptics.

Main Methods:

  • A clinical study involving 20 hospitalized patients with acute manic disorders.
  • Daily administration of clonidine at doses ranging from 450-750 micrograms for one month.
  • Monitoring of manic symptoms, patient tolerance, and adverse effects.

Main Results:

  • Excellent tolerance to clonidine was observed in all patients.
  • A significant decrease in manic symptoms was noted in 65% of patients within ten days.
  • Clonidine demonstrated rapid efficacy across all manic syndrome symptoms, with sustained effects throughout the study.
  • The supra-sedation effect was considerably lower compared to neuroleptics.

Conclusions:

  • Clonidine is an effective and well-tolerated treatment for acute manic disorders.
  • Its rapid onset, sustained efficacy, and favorable side effect profile, particularly reduced sedation, represent a practical advancement in acute manic episode management.
  • Further research into clonidine's mechanism in treating mania is warranted.

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