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Updated: May 24, 2026

Contractility Measurements of Human Uterine Smooth Muscle to Aid Drug Development

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Published on: January 26, 2018

Tocolytic therapy for acute preterm labor.

Adi Abramovici¹, Jessica Cantu, Sheri M Jenkins

¹Division of Maternal-Fetal Medicine, University of Alabama, Birmingham, 619 19th Street South 176F 10270C, Birmingham, AL 35249-7333, USA. adi.abramovici@obgyn.uab.edu

Obstetrics and Gynecology Clinics of North America

|February 29, 2012

Summary

This summary is machine-generated.

Preterm labor treatments are challenging due to multiple causes. This review summarizes common tocolytics, their efficacy, and side effects for optimal obstetric care.

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Area of Science:

Obstetrics and Gynecology
Pharmacology

Background:

Preterm labor pathophysiology is multifactorial and poorly understood, involving infection, inflammation, ischemia, and other factors.
Current therapies for preterm labor are suboptimal due to the diverse underlying causes and limitations in clinical study methodologies.
No single tocolytic agent effectively treats all mechanisms of preterm labor.

Purpose of the Study:

To review commonly used tocolytic agents for preterm labor.
To summarize their mechanisms of action, side effects, and clinical efficacy data.
To aid in selecting appropriate first-line tocolytic therapy based on gestational age and patient factors.

Main Methods:

Literature review of commonly used tocolytic agents.
Analysis of mechanisms of action, side effect profiles, and clinical efficacy.
Evaluation of factors influencing first-line therapy selection, including gestational age.

Main Results:

Tocolytic agents inhibit uterine contractility, but efficacy varies.
Indomethacin may be a first choice before 32 weeks gestation due to efficacy and minimal side effects.
Nifedipine is a reasonable choice between 32-34 weeks, avoiding fetal risks associated with indomethacin at later gestations.

Conclusions:

Effective tocolysis aims to complete glucocorticoid courses and facilitate neonatal care.
First-line tocolytic choice depends on gestational age, patient history, side effects, and response.
This review provides a summary of tocolytics to guide clinical decision-making in preterm labor management.