Related Experiment Video
Updated: May 24, 2026

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy
Published on: July 14, 2023
[Combination or sequential treatment using PTH and anti-resorption therapies]
Hisanori Suzuki1, Yasuhiro Takeuchi
1Toranomon Hospital Endocrine Center, Japan.
Abstract:
PTH increases bone formation and has an anabolic effect on bone. Antiresorptive drugs such as bishopshonateand selective estrogen receptor modulator (SERM) inhibit bone resorption and increase bone mineral density (BMD) . Efficacy of combinationtreatment with PTH and antiresorption drugshas been investigated. It has been reported that single intravenous infusion of zoledronic acid along with daily subcutaneous injection of PTH (1-34) (teriparatide) increases both spine and hip BMD. On the other hand, daily oral alendronate and daily PTH (1-84) showed no additive effects. Patients who had been treated with antiresorption drugs showed somewhat blunt but significant positive response to teriparatide. It warrants sequential therapy with teriparatide following antiresorption drugs that is common in daily practice of osteoporosis. Since a period of PTH administration is limited up to 24 months and bone mineral density starts to decreases shortly after discontinuation of PTH, sequential treatment with antiresorptive agents following PTH is highly recommended.
Related Concept Videos
Peptic Ulcer Disease IV: Management
The therapeutic approach involves ensuring adequate rest, implementing drug therapy, promoting smoking cessation, making dietary modifications, and emphasizing long-term follow-up care.
Pharmacological management
The prevailing therapy for peptic ulcers involves a combination of managing the patient's current medication...
Hormones and Bone Tissue
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Treating Helicobacter pylori in Peptic Ulcers: Antimicrobial Therapy
Urinary Tract Calculi III: Medical Management
Chronic Kidney Disease III: Interprofessional Care
Urinary Tract Calculi IV: Nutrition Therapy and Prevention