Related Experiment Video
Updated: May 24, 2026
03:57
Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy
Published on: July 14, 2023
[Combination or sequential treatment using PTH and anti-resorption therapies]
Hisanori Suzuki1, Yasuhiro Takeuchi
1Toranomon Hospital Endocrine Center, Japan.
Clinical Calcium
|February 29, 2012
Summary
Parathyroid hormone (PTH) and antiresorptive drugs can be used to treat osteoporosis. Sequential therapy, using antiresorptive drugs after PTH treatment, is recommended for sustained bone mineral density gains.
Area of Science:
- Endocrinology
- Bone Biology
- Pharmacology
Background:
- Parathyroid hormone (PTH) exhibits anabolic effects, promoting bone formation.
- Antiresorptive drugs, including bisphosphonates and selective estrogen receptor modulators (SERMs), inhibit bone resorption and increase bone mineral density (BMD).
- Combination therapies of PTH and antiresorptive agents have been explored for osteoporosis management.
Purpose of the Study:
- To investigate the efficacy of combined and sequential treatment strategies involving PTH and antiresorptive drugs.
- To evaluate the impact of prior antiresorptive therapy on the response to PTH treatment.
- To determine optimal therapeutic sequences for maximizing bone mineral density (BMD) in osteoporosis.
Main Methods:
- Review of studies examining the effects of PTH (1-34, teriparatide) and PTH (1-84) in combination with antiresorptive drugs (e.g., zoledronic acid, alendronate).
- Analysis of patient responses based on prior treatment history with antiresorptive agents.
- Assessment of BMD changes following different treatment regimens and discontinuation of PTH.
Main Results:
- Combination of zoledronic acid with daily subcutaneous PTH (1-34) increased both spine and hip BMD.
- Daily oral alendronate with daily PTH (1-84) did not show additive effects.
- Patients previously treated with antiresorptive drugs demonstrated a significant, albeit blunted, positive response to teriparatide.
Conclusions:
- Sequential therapy with teriparatide following antiresorptive drug treatment is a common and effective practice for osteoporosis.
- Bone mineral density (BMD) tends to decrease shortly after PTH discontinuation, highlighting the need for continued management.
- Sequential treatment with antiresorptive agents after a course of PTH is highly recommended to maintain BMD gains.
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