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Related Concept Videos

Urinary Tract Infection II: Pathophysiology01:25

Urinary Tract Infection II: Pathophysiology

The pathophysiology of urinary tract infections (UTIs) encompasses several progressive stages, beginning with bacterial colonization and culminating in potential systemic complications if untreated. UTIs are primarily initiated by bacteria, such as Escherichia coli, which often originate from the gastrointestinal tract and migrate to the urinary system through the periurethral area. This migration can occur via several routes, including improper hygiene practices, sexual activity, or...
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Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
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Acute Pyelonephritis II: Diagnostic Studies and Management

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Bacterial Meningitis I: Introduction01:22

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A healthcare provider can diagnose a urinary tract infection (UTI) through several methods:Medical History and Symptoms: The provider will take a detailed medical history and ask about symptoms such as frequent urination, burning sensation during urination, and lower abdominal pain.Urinalysis: A clean-catch urine sample is collected in a sterile container and tested for the presence of bacteria, white blood cells (leukocytes), nitrites, blood, and protein. The presence of leukocytes and...
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Updated: May 24, 2026

Povidone Iodine Rectal Preparation at Time of Prostate Needle Biopsy is a Simple and Reproducible Means to Reduce Risk of Procedural Infection
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Povidone Iodine Rectal Preparation at Time of Prostate Needle Biopsy is a Simple and Reproducible Means to Reduce Risk of Procedural Infection

Published on: September 21, 2015

Bacterial sepsis following prostatic biopsy.

Luca Carmignani1, Stefano Picozzi, Matteo Spinelli

  • 1Urology Department, IRCCS Policlinico San Donato, University of Milan, Via Morandi 30, 20097, San Donato Milanese, Milan, Italy.

International Urology and Nephrology
|February 29, 2012
PubMed
Summary

Transrectal prostate biopsies can lead to sepsis, primarily from multidrug-resistant Escherichia coli. Early recognition and prompt carbapenem treatment are crucial for preventing severe outcomes in sepsis patients.

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Last Updated: May 24, 2026

Povidone Iodine Rectal Preparation at Time of Prostate Needle Biopsy is a Simple and Reproducible Means to Reduce Risk of Procedural Infection
05:32

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Transperineal Prostate Biopsy Using a Cone-shaped Double-hole Method with Dual-plane Probe Guidance
05:35

Transperineal Prostate Biopsy Using a Cone-shaped Double-hole Method with Dual-plane Probe Guidance

Published on: June 6, 2025

Area of Science:

  • Urology
  • Infectious Diseases
  • Microbiology

Background:

  • Prostate biopsy complications, including sepsis, remain a concern despite technological advancements.
  • Septic complications can arise following transrectal prostate biopsy procedures.

Purpose of the Study:

  • To prospectively monitor major septic complications after transrectal prostate biopsy.
  • To identify causative agents, describe clinical courses, and provide evidence-based guidelines.

Main Methods:

  • Prospective study conducted from January 2009 to September 2010.
  • Complications were assessed via telephone interviews with patients.

Main Results:

  • Ten patients (2.2%) developed urosepsis, with three progressing to septic shock.
  • Escherichia coli was the predominant pathogen (8/9 positive blood cultures), with significant fluoroquinolone resistance and multidrug-resistant organism (MDRO) prevalence.
  • One patient died from multiorgan failure; others required hospitalization averaging 9 days.

Conclusions:

  • Escherichia coli exhibits increasing drug resistance, necessitating vigilance for multidrug-resistant organisms (MDROs).
  • Early suspicion of MDRO E. coli infection in patients with sepsis signs post-biopsy is vital.
  • Urgent hospitalization and empirical carbapenem therapy are recommended for suspected sepsis following transrectal prostate biopsy.