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Immunoexpression of cyclooxygenase-2 in primary gastric carcinomas and lymph node metastases
Paulo R C Almeida1, Francisco V A Ferreira, Cássio C Santos
1Faculty of Medicine, Federal University of Ceará, 60.430-350 Fortaleza, Brazil. paulo.almeida@ufc.br
Aim:
To evaluate immunoexpression of cyclooxygenase-2 (COX-2) in primary gastric carcinomas and respective lymph node metastases.
Methods:
Immunohistochemistry to analyze COX-2 expression was performed on tissue microarray slices obtained from 36 specimens of gastrectomy and satellite lymph nodes from patients with gastric carcinoma.
Results:
Immunostaining was seen in most cases, and COX-2 expression was higher in lymph node metastases than in corresponding primary gastric tumors of intestinal, diffuse and mixed carcinomas, with a statistically significant difference in the diffuse histotype (P = 0.0108).
Conclusion:
COX-2 immunoexpression occurs frequently in primary gastric carcinomas, but higher expression of this enzyme is observed in lymph node metastases of the diffuse histotype.
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