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Updated: Jan 18, 2026

Primary Human Nasal Epithelial Cells: Biobanking in the Context of Precision Medicine
Published on: April 22, 2022
Advances in cell and gene-based therapies for cystic fibrosis lung disease
Mayumi Oakland1, Patrick L Sinn, Paul B McCray
1Department of Microbiology, Carver College of Medicine, The University of Iowa, Iowa City, Iowa 52242, USA.
Abstract:
Cystic fibrosis (CF) is a disease characterized by airway infection, inflammation, remodeling, and obstruction that gradually destroy the lungs. Direct delivery of the cystic fibrosis transmembrane conductance regulator (CFTR) gene to airway epithelia may offer advantages, as the tissue is accessible for topical delivery of vectors. Yet, physical and host immune barriers in the lung present challenges for successful gene transfer to the respiratory tract. Advances in gene transfer approaches, tissue engineering, and novel animal models are generating excitement within the CF research field. This review discusses current challenges and advancements in viral and nonviral vectors, cell-based therapies, and CF animal models.
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