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Updated: May 24, 2026

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
Published on: March 30, 2018
Malignant granular cell tumor of the posterior mediastinum with dissemination
Masayuki Nakao1, Tomoyuki Hishida, Genichiro Ishii
1Division of Thoracic Surgery, Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan. manakao@east.ncc.go.jp
Abstract:
A 66-year-old man presented with severe back pain. Imaging studies revealed a well-circumscribed mass in the left posterior mediastinum. Because of pleural dissemination observed at thoracotomy, palliative resection was performed to relieve his back pain. Histologically, the tumor was composed of cells with large eosinophilic and granular cytoplasm, which were strongly positive for S-100. Mediastinal malignant granular cell tumor with pleural dissemination is extremely unusual.
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