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Updated: May 24, 2026
Functional Assessment of Intestinal Motility and Gut Wall Inflammation in Rodents: Analyses in a Standardized Model of Intestinal Manipulation
Published on: September 11, 2012
[Effects of Na-FA on gastrointestinal movement and gastric ulcer in mice]
Yue-Mei Li1, Bao-Cai Li, Peng Li
1Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650224, China. liyuemei5566@hotmail.com
Objective:
To research the effects of Na-FA on gastrointestinal movement and gastriculcer in mice.
Methods:
Using charcoal powder as an indicator, the effects of FA-Na on bowel movement of mice was evaluated by determining the propulsive percent-age of charcoal powder in normal mice, inhibition of small intestinal propulsion model induced by Compound Diphenoxylate and spleen asthenia and diarrhea model caused by Rheum officinale Baill; The acute gastric ulcer model was induced by intragastric alcohol given orally, the protective effect of FA-Na given ahead on gastric injury was evaluated, the ulcer index and the inhibition ratio of ulcer was calculated.
Results:
FA-Na (intragastric administration) had inhibit effect on normal mice and diarrhea model caused by Rheum officinale, significantly synergetic effect on gastrointestinal asynersis induced by Compound Diphenoxylate, and protective effect on mice gastric mucosal injury cause by dehydrated alcohol. Compared with the positive control drug Ranitidine, the ulcer index and ulcer inhibition ratio large doses of FA-Na had no significant difference.
Conclusion:
The acute toxicity of FA-Na is very low, it has the effects of antidiarrheal and anti-gastric ulcer.
