Statistical properties of ABR amplitudes and latencies. Implications for computation of reference limits and relation...

A method for statistical analysis and computation of reference limits for ABR latency and amplitude variables is presented. Condensation and rarefaction ABRs from 47 healthy controls aged 4-58 years were investigated. With respect to gaussianity of distributions, the square root transformation was superior to the logarithmic transformation for amplitudes, while the logarithmic transformation performed better for amplitude ratios. Wave V latency and the I-V interpeak latency were nearly normally distributed, while other latencies and inter-peak latencies displayed varying displacement from a normal distribution. Rarefaction ABR distributions were slightly closer to normality than were condensation ABRs. Amplitude vs. following amplitude and latency vs. amplitude correlation coefficients were larger for R than for C click ABRs; thus R clicks seem to evoke a better synchronized neural volley. Most of the correlation between amplitude and latency could be explained by the influence of age and sex. Hence, age and sex matched reference limits for ABR amplitudes, without correction for latency, seem to be adequate in practical clinical work.