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Related Concept Videos

Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
Stem Cell Culture01:17

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...

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Related Experiment Video

Updated: May 24, 2026

Construction of Defined Human Engineered Cardiac Tissues to Study Mechanisms of Cardiac Cell Therapy
11:51

Construction of Defined Human Engineered Cardiac Tissues to Study Mechanisms of Cardiac Cell Therapy

Published on: March 1, 2016

Cell therapy in the heart.

Latifa S Abdelli1, Hilda Merino, Crystal M Rocher

  • 1Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, FL 32816, USA.

Canadian Journal of Physiology and Pharmacology
|March 1, 2012
PubMed
Summary

Cell therapy shows promise for heart disease by improving cardiac function, but long-term benefits remain unclear. Further research into cell transplantation in the myocardium is needed.

Area of Science:

  • Cardiovascular research
  • Regenerative medicine
  • Stem cell biology

Background:

  • Heart disease presents significant adverse effects, driving the need for novel therapeutic strategies.
  • Cell therapy, particularly stem cell transplantation, is being investigated as a potential treatment for myocardial injury.
  • Existing studies show transplanted cells can integrate, differentiate, and initially improve heart function.

Purpose of the Study:

  • To review current literature on cell transplantation for heart disease.
  • To analyze findings from both animal models and human clinical trials.
  • To discuss the efficacy and limitations of cell therapy in treating myocardial damage.

Main Methods:

  • Comprehensive literature search of experimental and clinical studies on cell transplantation in cardiology.

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Cell-based Therapy for Heart Failure in Rat: Double Thoracotomy for Myocardial Infarction and Epicardial Implantation of Cells and Biomatrix
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Cell-based Therapy for Heart Failure in Rat: Double Thoracotomy for Myocardial Infarction and Epicardial Implantation of Cells and Biomatrix

Published on: September 22, 2014

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Last Updated: May 24, 2026

Construction of Defined Human Engineered Cardiac Tissues to Study Mechanisms of Cardiac Cell Therapy
11:51

Construction of Defined Human Engineered Cardiac Tissues to Study Mechanisms of Cardiac Cell Therapy

Published on: March 1, 2016

Isolation, Characterization, and Differentiation of Cardiac Stem Cells from the Adult Mouse Heart
11:45

Isolation, Characterization, and Differentiation of Cardiac Stem Cells from the Adult Mouse Heart

Published on: January 7, 2019

Cell-based Therapy for Heart Failure in Rat: Double Thoracotomy for Myocardial Infarction and Epicardial Implantation of Cells and Biomatrix
09:11

Cell-based Therapy for Heart Failure in Rat: Double Thoracotomy for Myocardial Infarction and Epicardial Implantation of Cells and Biomatrix

Published on: September 22, 2014

  • Analysis of data regarding cell engraftment, differentiation, and functional outcomes in injured myocardium.
  • Evaluation of short-term versus long-term results from clinical trials.

    • Main Results:

    • Transplanted stem cells demonstrate engraftment and differentiation capabilities in the myocardium.
    • Initial improvements in cardiac function are observed post-transplantation in clinical trials.
    • These functional improvements tend to diminish by 18 months in long-term follow-ups.

    Conclusions:

    • Cell therapy holds potential for managing heart disease complications.
    • Conflicting results in clinical trials highlight the need for further investigation into long-term efficacy.
    • Understanding the mechanisms and optimizing cell transplantation protocols are crucial for future success.