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Updated: May 24, 2026

Simultaneous Measurement of HDAC1 and HDAC6 Activity in HeLa Cells Using UHPLC-MS
Published on: August 10, 2017
HDAC6 at the Intersection of Neuroprotection and Neurodegeneration
Constantin d'Ydewalle1, Elke Bogaert, Ludo Van Den Bosch
1Vesalius Research Center, VIB, Campus Gasthuisberg, Leuven, Belgium.
Abstract:
Histone deacetylase 6 (HDAC6) catalyzes multiple reactions. We summarize the current knowledge on HDAC6, its targets and functions. Among others, HDAC6 recognizes damaged proteins and assures that these proteins are destroyed by autophagy. On the other hand, HDAC6 also modifies the tracks used by the clearance mechanism so that axonal transport becomes less efficient. We hypothesize that a disturbance in the equilibrium between the different functions of HDAC6 could play an important role in neurodegeneration.
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