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Chronic lymphocytic leukaemia in the cat: 18 cases (2000-2010)
M W Campbell1, P R Hess, L E Williams
1Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA.
Veterinary and Comparative Oncology
|March 1, 2012
Summary
This study characterizes feline chronic lymphocytic leukemia (CLL) in 18 cats. Older cats with CLL responded well to oral chlorambucil and prednisolone, achieving significant remission and survival times.
Area of Science:
- Veterinary Medicine
- Oncology
- Hematology
Background:
- Information on feline chronic lymphocytic leukemia (CLL) presentation, behavior, treatment, and prognosis is limited.
- Further research is needed to fully understand and manage this feline hematologic malignancy.
Purpose of the Study:
- To describe the clinical presentation, treatment response, and prognosis of feline chronic lymphocytic leukemia (CLL).
- To provide essential data for veterinary oncologists and clinicians managing feline CLL cases.
Main Methods:
- A multi-institutional retrospective study analyzed data from 18 cats diagnosed with CLL between 2000 and 2010.
- CLL diagnosis required mature lymphocytosis and confirmed clonal lymphoid population, with concurrent cytopenia or bone marrow involvement.
Main Results:
- The median age of affected cats was 12.5 years, with chronic weight loss being the most common sign.
- 89% of cats treated with chlorambucil and prednisolone achieved complete or partial remission.
- Median overall remission was 15.7 months, and median survival was 14.4 months.
Conclusions:
- Feline chronic lymphocytic leukemia (CLL) primarily affects older cats.
- Treatment with oral chlorambucil and prednisolone appears effective, leading to favorable outcomes.
