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Reference values for airway resistance in newborns, infants and preschoolers from a Latin American population
Laura G Gochicoa1, Laura P Thomé-Ortiz, María E Y Furuya
1Center for Evaluation of the Paediatric Asthma Patient, Centro Médico Santa Teresa, Texcoco, México.
Insights
This study establishes airway resistance (Rint) reference values for Mexican children, finding Rint decreases with height. These findings are crucial for pediatric respiratory health assessments in diverse populations.
Area of Science:
- Pediatric Pulmonology
- Respiratory Physiology
Background:
- Limited reference values for airway resistance (Rint) exist for Latin American and Mexican children.
- Previous studies on Rint reference values primarily included children aged 3 years and older, leaving a gap for newborns and infants.
Purpose of the Study:
- To determine Rint reference values for Mexican children, including newborns and infants.
- To establish regression equations for Rint based on height in pediatric populations.
Main Methods:
- Airway resistance (Rint) was measured using the interrupter technique in two groups: healthy preschool children and sedated newborns, infants, and preschool children hospitalized for non-cardiopulmonary conditions.
- Regression analysis was used to determine the relationship between Rint and anthropometric measurements (age, weight, height).
Main Results:
- Rint values showed an inverse association with age, weight, and height, with height being the strongest predictor.
- Linear regression equations were derived for Rint based on height for both study groups.
- A trend of slightly higher Rint values in girls was observed, which diminished as height increased.
Conclusions:
- New Rint reference values applicable to Mexican children were established.
- The findings suggest these Rint values may also be relevant for pediatric populations with similar ancestries.
- An inverse relationship between Rint and height was confirmed, highlighting significant between-subject variability.
Background And Objective:
Several studies have determined reference values for airway resistance measured by the interrupter technique (Rint) in paediatric populations, but only one has been done on Latin American children, and no studies have been performed on Mexican children. Moreover, these previous studies mostly included children aged 3 years and older; therefore, information regarding Rint reference values for newborns and infants is scarce.
Methods:
Rint measurements were performed on preschool children attending eight kindergartens (Group 1) and also on sedated newborns, infants and preschool children admitted to a tertiary-level paediatric hospital due to non-cardiopulmonary disorders (Group 2).
Results:
In both groups, Rint values were inversely associated with age, weight and height, but the strongest association was with height. The linear regression equation for Group 1 (n = 209, height 86-129 cm) was Rint = 2.153 - 0.012 × height (cm) (standard deviation of residuals 0.181 kPa/L/s). The linear regression equation for Group 2 (n = 55, height 52-113 cm) was Rint = 4.575 - 0.035 × height (cm) (standard deviation of residuals 0.567 kPa/L/s). Girls tended to have slightly higher Rint values than boys, a difference that diminished with increasing height.
Conclusions:
In this study, Rint reference values applicable to Mexican children were determined, and these values are probably also applicable to other paediatric populations with similar Spanish-Amerindian ancestries. There was an inverse relationship between Rint and height, with relatively large between-subject variability.
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