Epidemiology in peptic ulcer disease. Current status and future aspects

Peptic ulcer incidence is declining. A decreased prevalence of smokers together with other factors have contributed to this change. The widespread use of non-steroidal anti-inflammatory drugs (NSAID) has increased the incidence of ulcer in the older population and serious complications, such as perforation and bleeding, have been observed especially in older women. Helicobacter pylori infection is virtually always present in duodenal and gastric ulcer and active chronic gastritis, but not prepyloric ulcer. The fact that this organism is not eradicated with the use of most drugs for peptic ulcer may explain the high rate of recurrence in ulcer disease since relapse rates are reported to be considerably lower when H. pylori is eradicated. In a substantial number of patients peptic ulcers are silent. These fall into two categories: the regular ulcer patient with relapses that heal spontaneously and rarely cause problems, and older patients without prior ulcer disease receiving NSAID treatment, presenting with a life-threatening complication as the first indication of ulcer disease. Despite all the new knowledge of peptic ulcer disease presented, the questions still outnumber the answers; it is therefore suggested that future research focus on the role of NSAIDs and H. pylori.