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Published on: July 19, 2018

Hemodialysis does not always protect against recurrence of Wegener's granulomatosis

R S Pedersen1, N A Aunsholt

  • 1First University Clinic of Internal Medicine, Aarhus Municipal Hospital, Denmark.

Scandinavian Journal of Urology and Nephrology
|January 1, 1990
PubMed

Hemodialysis may protect against disease activity in Wegener's granulomatosis. We report here a 41-year-old woman with Wegener's granulomatosis, in whom renal transplantation was performed after a 10-month period of hemodialysis during which no signs of disease activity were detected. Recurrence of disease did, however, take place 2 years after renal allograft transplantation despite immunosuppressive therapy with cyclosporine A and prednisone. Reinstitution of hemodialysis and graftectomy did not improve the patient's condition but plasmapheresis and treatment with cyclophosphamide and prednisone eliminated all signs of disease within a fortnight. A proposal for better maintenance of these patients is made.

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