Related Experiment Video
Updated: May 24, 2026

Combined Immunofluorescence and DNA FISH on 3D-preserved Interphase Nuclei to Study Changes in 3D Nuclear Organization
Published on: February 3, 2013
Distance-based phenotypic association analysis of DNA sequence data
Doyoung Chung1, Qunyuan Zhang, Aldi T Kraja
1Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St, Louis, MO 63110, USA. doyoung.chung@wustl.edu.
Abstract:
As the cost of sequencing decreases, the demand for association tests that use exhaustive DNA sequence information increases. One such association test is multivariate distance matrix regression (MDMR). We explore some of the features of MDMR using Genetic Analysis Workshop 17 simulated data in search of potential improvements in distance measures. We used genotype data from 697 unrelated individuals, in 200 replications, to test the power of MDMR to detect 13 trait Q2 causative genes based on the Euclidean distance metric. We also estimated the false-positive rate of MDMR using 508 control genes. In addition, we compared MDMR with Mantel's test and collapsing analysis for rare variants. MDMR performed comparably well even with the Euclidean distance measure.
More Related Videos
11:35Screening for Functional Non-coding Genetic Variants Using Electrophoretic Mobility Shift Assay (EMSA) and DNA-affinity Precipitation Assay (DAPA)
Published on: August 21, 2016
08:27Large-Scale Multi-Omics Genome-Wide Association Studies (Mo-GWAS): Guidelines for Sample Preparation and Normalization
Published on: July 27, 2021
Related Concept Videos
Genome-wide Association Studies-GWAS
GWAS does not require the identification of the target gene involved in...
Evolutionary Relationships through Genome Comparisons
Modern Molecular Taxonomy
Pedigree Analysis
Sanger Sequencing
Epistasis Analysis