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Scale-Up Processes

Scale-Up Processes

The scale-up of microbial fermentation processes is essential in industrial biotechnology, allowing the transition from laboratory-scale experiments to commercial-scale production while aiming to maintain product yield and quality. This process requires meticulous adjustment of equipment design, process parameters, and contamination control strategies to accommodate increasing culture volumes.At the laboratory scale, cultures are typically maintained in 1 to 10-liter glass or autoclavable...

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Updated: May 24, 2026

An Open-Source Normothermic Perfusion System Designed for Research Scientists

An Open-Source Normothermic Perfusion System Designed for Research Scientists

Published on: July 18, 2025

Challenges in scaling up a perfusion process

Vana Raja¹, Saravanan Desan¹, Ankur Bhatnagar¹

¹Cell Culture Lab, Biocon Limited, Bangalore, India.

BMC Proceedings

|March 1, 2012

Summary

No abstract available in PubMed .

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