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LASSO model selection with post-processing for a genome-wide association study data set

Allan J Motyer1, Chris McKendry, Sally Galbraith

  • 1Prince of Wales Clinical School, University of New South Wales, New South Wales 2052, Australia. a.motyer@unsw.edu.au.

BMC Proceedings
|March 1, 2012
PubMed

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Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...