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Preparing T Cell Growth Factor from Rat Splenocytes
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Published on: October 31, 2007

Production and purification of TGFb-1 in CHO-Cells

Estabraq Abdulkerim1, Sabrina Baganz1, Axel Schambach2

  • 1Institute of Technical Chemistry, Leibniz University of Hanover, 30167 Hannover, Germany.

BMC Proceedings
|March 1, 2012
PubMed
Abstract

No abstract available in PubMed .

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TGF - β Signaling Pathway01:16

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The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors are of three kinds RI, RII, and RIII. The RI...

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