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Notch Signaling Pathway03:14

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
Notch Signaling Pathway03:14

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

Role Of Notch Signalling In Intestinal Stem Cell Renewal

Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
Investigation of Disease Outbreaks01:23

Investigation of Disease Outbreaks

Multistate foodborne outbreaks pose significant public health risks and require meticulous investigation to identify sources and implement control measures. The Centers for Disease Control and Prevention (CDC) utilizes a dynamic seven-step process for these investigations, integrating data from laboratories, interviews, and environmental assessments to protect public health.Outbreak Detection: The detection of multistate outbreaks typically begins with PulseNet, the CDC's national laboratory...
Infectious Diseases and Their Occurrence01:28

Infectious Diseases and Their Occurrence

Infectious diseases appear in populations through various transmission patterns, influenced by pathogen characteristics, population immunity, environmental conditions, and social behavior. Understanding these patterns is essential for effective public health surveillance and intervention. These categories—sporadic, outbreak, epidemic, pandemic, and endemic—help frame the nature and scope of disease events.Sporadic diseases occur irregularly and infrequently, without a predictable temporal or...
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...

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Related Experiment Video

Updated: May 24, 2026

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer
09:08

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer

Published on: January 12, 2020

Notch and disease: a growing field.

Angeliki Louvi1, Spyros Artavanis-Tsakonas

  • 1Department of Neurosurgery and Neurobiology, Program on Neurogenetics, Yale School of Medicine, New Haven, CT, United States. angeliki.louvi@yale.edu

Seminars in Cell & Developmental Biology
|March 1, 2012
PubMed
Summary

Notch signaling controls cell fate during development and in adult stem cells. This review overviews Notch pathway roles in human diseases and discusses experimental models for understanding disease mechanisms and developing therapies.

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Published on: January 16, 2019

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Last Updated: May 24, 2026

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer
09:08

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer

Published on: January 12, 2020

Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation
07:15

Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation

Published on: January 16, 2019

Area of Science:

  • Cellular and Molecular Biology
  • Developmental Biology
  • Pathology

Background:

  • Notch signaling is crucial for cell fate determination throughout development.
  • The Notch pathway plays a significant role in adult stem cell biology.
  • Complex regulatory mechanisms govern Notch pathway activity.

Purpose of the Study:

  • To provide an overview of Notch signaling's involvement in human diseases.
  • To highlight experimental models used to study Notch-related pathologies.
  • To aid in defining rational therapeutic strategies for Notch-associated conditions.

Main Methods:

  • Literature review of Notch signaling in human disease.
  • Analysis of experimental models for Notch-related pathologies.
  • Synthesis of current understanding of Notch pathway pathobiology.

Main Results:

  • Notch signaling involvement in human disease is pleiotropic and widespread.
  • Numerous Notch-related pathologies have been identified.
  • Experimental systems offer insights into disease mechanisms.

Conclusions:

  • Understanding Notch signaling's complex role in development and stem cells is key to addressing its involvement in disease.
  • Further research using experimental models can elucidate pathobiology and guide therapeutic development.
  • Targeting the Notch pathway presents challenges but holds therapeutic potential.