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Cystatin C levels in patients with dipper and nondipper hypertension

Serkan Ordu1, Hakan Ozhan, Recai Alemdar

  • 1Department of Cardiology, Medicine Faculty, Duzce University, Duzce, Turkey.

Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research
|March 1, 2012
PubMed

Insights

Nondipper hypertension is linked to increased cardiovascular risk. This study found higher cystatin C levels in nondipper hypertension patients, suggesting it may predict this blood pressure pattern.

Area of Science:

  • Cardiology
  • Nephrology
  • Biochemistry

Background:

  • Nondipper hypertension presents a greater cardiovascular risk compared to normotension.
  • Understanding biomarkers associated with nondipper hypertension is crucial for risk stratification.

Purpose of the Study:

  • To investigate serum cystatin C levels in patients with dipper versus nondipper hypertension.
  • To determine if cystatin C is associated with the nondipping blood pressure pattern.

Main Methods:

  • Ambulatory blood pressure monitoring (ABPM) was used to classify 88 hypertensive patients into dipper and nondipper groups.
  • Clinical, laboratory, and ABPM data were compared between the two groups.
  • Statistical analyses, including regression, were performed to assess cystatin C's relationship with blood pressure patterns.

Main Results:

  • Patients with nondipper hypertension were older than those with dipper hypertension.
  • Serum cystatin C levels were significantly higher in the nondipper group.
  • Cystatin C was independently associated with the nondipping pattern and negatively correlated with nocturnal systolic blood pressure fall.

Conclusions:

  • Elevated serum cystatin C levels are observed in patients with nondipper hypertension.
  • Cystatin C may serve as a predictor for the nondipping blood pressure phenotype in hypertensive individuals.
Abstract

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