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Related Experiment Video

Updated: May 24, 2026

A Mouse Distraction Osteogenesis Model
04:24

A Mouse Distraction Osteogenesis Model

Published on: November 14, 2018

Induced osteogenesis using a new periosteal distractor.

Osama Zakaria1, Marwa Madi, Shohei Kasugai

  • 1Department of Oral Implantology and Regenerative Dental Medicine, Tokyo Medical and Dental University, Tokyo, Japan. Osama.irm@tmd.ac.jp

Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons
|March 1, 2012
PubMed
Summary

A novel titanium mesh device effectively induced bone formation through periosteal distraction in rabbits. This technique shows promise for ridge augmentation in oral surgery.

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Area of Science:

  • Biomaterials Engineering
  • Regenerative Medicine
  • Surgical Innovation

Background:

  • Periosteal distraction is a method to expand soft tissues.
  • Developing new devices for controlled tissue expansion is crucial for regenerative applications.

Purpose of the Study:

  • To evaluate induced osteogenesis via periosteal distraction using a newly developed titanium mesh device.
  • To assess the efficacy of the device in a rabbit model.

Main Methods:

  • A titanium mesh device was used to distract the periosteum in 12 rabbits over 6 weeks.
  • Periosteal distraction was performed at a rate of 0.5 mm every 12 hours.
  • Histological and radiographic evaluations assessed newly formed bone.

Main Results:

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An Efficient and Reproducible Protocol for Distraction Osteogenesis in a Rat Model Leading to a Functional Regenerated Femur
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An Efficient and Reproducible Protocol for Distraction Osteogenesis in a Rat Model Leading to a Functional Regenerated Femur

Published on: October 23, 2017

Creating Rigidly Stabilized Fractures for Assessing Intramembranous Ossification, Distraction Osteogenesis, or Healing of Critical Sized Defects
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Creating Rigidly Stabilized Fractures for Assessing Intramembranous Ossification, Distraction Osteogenesis, or Healing of Critical Sized Defects

Published on: April 11, 2012

Related Experiment Videos

Last Updated: May 24, 2026

A Mouse Distraction Osteogenesis Model
04:24

A Mouse Distraction Osteogenesis Model

Published on: November 14, 2018

An Efficient and Reproducible Protocol for Distraction Osteogenesis in a Rat Model Leading to a Functional Regenerated Femur
09:26

An Efficient and Reproducible Protocol for Distraction Osteogenesis in a Rat Model Leading to a Functional Regenerated Femur

Published on: October 23, 2017

Creating Rigidly Stabilized Fractures for Assessing Intramembranous Ossification, Distraction Osteogenesis, or Healing of Critical Sized Defects
07:35

Creating Rigidly Stabilized Fractures for Assessing Intramembranous Ossification, Distraction Osteogenesis, or Healing of Critical Sized Defects

Published on: April 11, 2012

  • The titanium mesh device successfully induced osteogenesis.
  • Significant soft tissue distraction was achieved after 6 weeks in the rabbit model.

Conclusions:

  • The developed device is slim and easy to use, offering potential for vertical and horizontal ridge augmentation.
  • Periosteal distraction speed may influence connective tissue growth at the distraction site.