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Related Experiment Video

Updated: May 24, 2026

Conjunctival Commensal Isolation and Identification in Mice

Conjunctival Commensal Isolation and Identification in Mice

Published on: May 1, 2021

Allergic conjunctivitis and dry eye syndrome.

Milton M Hom¹, Andrew L Nguyen, Leonard Bielory

¹eyemage@mminternet.com

Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology

|March 1, 2012

Summary

Many patients with itchy eyes (allergic conjunctivitis) also experience dry eyes and redness, indicating a common overlap between these ocular surface conditions. These findings highlight the frequent comorbidity of allergic conjunctivitis and dry eye syndrome.

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Area of Science:

Ophthalmology
Ocular Surface Disease

Background:

Allergic conjunctivitis (AC) and dry eye syndrome (DES) are prevalent inflammatory disorders affecting the ocular surface.
These conditions can coexist in the same patient.

Purpose of the Study:

To investigate the potential comorbidity and symptom overlap between AC and DES.
To analyze the relationship between self-reported itchiness, dryness, and redness in ocular surface disease.

Main Methods:

A survey of 689 patients in an optometric setting using the Subjective Evaluation of Symptom of Dryness questionnaire.
Patients were categorized based on reported levels of itchiness, dryness, and redness.

Main Results:

Clinically significant itchiness was reported by 28.2%, dry eyes by 35.8%, and redness by 28.2% of patients.
A significant overlap was observed: 57.7% of patients with itchiness also had dryness, and 45.3% with dryness reported itchiness.
Itchiness, dryness, and redness were statistically interdependent (P<.001), with higher odds of co-occurrence.

Conclusions:

A majority of patients experiencing symptoms consistent with AC also present with dry eyes and redness.
These results suggest that AC and DES frequently occur concurrently in symptomatic patients.