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Related Experiment Videos

Differences in norepinephrine and dopamine neurotransmitter storage systems.

M K Sanghera, D C German, R S Kiser

    Brain Research Bulletin
    |March 1, 1979
    PubMed
    Summary

    D-amphetamine reduces dopamine and norepinephrine neuron activity. A tyrosine hydroxylase inhibitor blocks this effect on dopamine but not norepinephrine, suggesting different neurotransmitter storage mechanisms.

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    Area of Science:

    • Neuroscience
    • Pharmacology

    Background:

    • Dopamine (DA) and norepinephrine (NE) are critical neurotransmitters involved in various brain functions.
    • Understanding their synthesis, storage, and release mechanisms is crucial for developing effective therapeutics.

    Purpose of the Study:

    • To investigate the differential effects of d-amphetamine (d-AMP) on dopamine and norepinephrine neuron firing rates.
    • To explore the role of tyrosine hydroxylase inhibition in modulating these effects.
    • To elucidate potential differences in neurotransmitter storage and release mechanisms between DA and NE neurons.

    Main Methods:

    • Electrophysiological recordings of DA neurons (substantia nigra zone compacta) and NE neurons (locus coeruleus).
    • Administration of d-amphetamine (d-AMP) to assess its impact on neuronal firing rates.

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  • Pretreatment and subsequent administration of alpha-methyl-para-tyrosine (alpha-MT), a tyrosine hydroxylase inhibitor, to evaluate its modulatory effects.

    • Main Results:

    • Low doses of d-AMP significantly decreased firing rates in both DA and NE neurons.
    • Alpha-MT pretreatment blocked d-AMP's effect on DA neuron firing but not NE neuron firing.
    • Alpha-MT administered after d-AMP reversed the effect on DA neurons but not NE neurons.
    • These findings indicate distinct storage and release mechanisms for DA and NE.

    Conclusions:

    • DA neurons exhibit a slower transfer between stored and newly synthesized neurotransmitter pools.
    • NE neurons demonstrate more rapid mobilization of stored neurotransmitters.
    • These differences in amine storage mechanisms explain the differential responses to d-AMP and tyrosine hydroxylase inhibition.