Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effects of an antiperspirant with emollients on foot-sweat accumulation and blister formation while walking in the heat.

Journal of the American Academy of Dermatology·1995
Same author

The achievement of isoeffective bronchial mucosal dose during endobronchial brachytherapy.

International journal of radiation oncology, biology, physics·1995
Same author

Entry of microbes into the host: using M cells to break the mucosal barrier.

Current opinion in immunology·1995
Same author

Derivation of the optimum dose per fraction from the linear quadratic model.

The British journal of radiology·1995
Same author

On the nature of the mutation in the nude rat.

Trends in genetics : TIG·1995
Same author

Radiotherapy and chemotherapy for inoperable non-small cell lung cancer.

Postgraduate medical journal·1995

Related Experiment Video

Updated: May 24, 2026

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
08:34

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

Malignant induction probability maps for radiotherapy using X-ray and proton beams.

C Timlin1, M Houston, B Jones

  • 1Particle Therapy Cancer Research Institute, Denys Wilkinson Building, Oxford, UK. Claire.Timlin@ptcri.ox.ac.uk

The British Journal of Radiology
|March 1, 2012
PubMed
Summary

This study visualizes cancer induction risk in radiotherapy. For proton therapy, increasing fields can raise risk, but protons offer lower risk for superficial tumors. Minimizing irradiated tissue volume is key to reducing overall risk.

More Related Videos

Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform
07:57

Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform

Published on: March 24, 2022

Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition
06:20

Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition

Published on: March 11, 2021

Related Experiment Videos

Last Updated: May 24, 2026

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
08:34

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform
07:57

Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform

Published on: March 24, 2022

Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition
06:20

Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition

Published on: March 11, 2021

Area of Science:

  • Medical Physics
  • Radiation Oncology
  • Computational Biology

Background:

  • Radiotherapy planning requires precise dose distribution visualization.
  • Assessing the risk of secondary cancer induction is crucial for long-term patient outcomes.
  • Current methods often lack integrated visualization of dose and cancer risk.

Purpose of the Study:

  • To develop and display Malignant Induction Probability (MIP) maps alongside dose distributions for X-ray and proton therapy.
  • To model cancer induction risk based on dose, fractionation, and relative biological effectiveness.
  • To explore the influence of treatment geometry on MIP.

Main Methods:

  • Utilized a linear quadratic model to calculate MIP, incorporating dose, fractionation, cell killing, and cancer induction.
  • Developed an interactive MATLAB program for visualizing dose distributions and MIP maps.
  • Modeled two scenarios: central tumor and superficial tumor, with varying treatment field options.

Main Results:

  • Proton therapy's MIP increases with the number of treatment fields, potentially exceeding X-ray MIP in some configurations.
  • Protons demonstrate lower MIPs for superficial targets due to the absence of exit dose.
  • A 'dose bath' significantly increases MIP (up to tenfold), highlighting the impact of scattered radiation.
  • MIP is influenced by treatment geometry, including beam path length and irradiated tissue volume.

Conclusions:

  • Three-dimensional visualization of carcinogenesis risk is achievable.
  • Reducing the volume of irradiated normal tissue is critical for minimizing total MIP.
  • Findings support the use of advanced treatment gantries and simplified field arrangements in particle therapy, respecting normal tissue constraints.