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Early retinal arteriolar changes and peripheral neuropathy in diabetes
Jie Ding1, Carol Y Cheung, M Kamran Ikram
1Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.
Diabetes Care
|March 1, 2012
Summary
Early retinal arteriolar abnormalities are linked to a higher likelihood of diabetic peripheral neuropathy (DPN) in individuals with diabetes. These retinal changes indicate microvascular dysfunction and serve as an independent risk factor for DPN.
Area of Science:
- Ophthalmology
- Neurology
- Diabetology
Background:
- Diabetic peripheral neuropathy (DPN) is a common complication of diabetes.
- Early detection of DPN risk factors is crucial for timely intervention.
- Retinal microvascular changes may serve as an early indicator of systemic microvascular dysfunction.
Purpose of the Study:
- To investigate the association between early retinal arteriolar abnormalities and the presence of DPN.
- To determine if retinal microvascular changes are independent predictors of DPN.
Main Methods:
- Analysis of data from 608 participants (aged 40-80) with diabetes from the Singapore Malay Eye Study.
- Digital retinal photography and quantitative sensory testing were performed.
- Retinal vascular caliber, arteriolar geometry, and signs of retinopathy were quantitatively and qualitatively assessed.
Main Results:
- Diabetic peripheral neuropathy (DPN) was present in 25.5% of participants.
- Suboptimal arteriolar caliber, larger arteriolar branching coefficient, diabetic retinopathy, and focal arteriolar narrowing were significantly associated with DPN.
- A greater number of retinal microvascular signs increased the likelihood of DPN.
Conclusions:
- Early retinal arteriolar abnormalities are independently associated with DPN in individuals with diabetes.
- Retinal microvascular dysfunction is an independent risk factor for DPN, irrespective of hyperglycemia and other vascular risk factors.
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