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Desmosomes in verrucous carcinoma of the head and neck

K Odar1, N Zidar, S Bonin

  • 1Institute of Pathology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia. katarina.odar@mf.uni-lj.si

Histology and Histopathology
|March 1, 2012
PubMed

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Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
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Strong contact points between adjacent cells anchor them to each other, forming tissues. Such anchoring junctions are of two types –  adherens junctions and desmosomes. Adherens junctions are abundant in tissues such as  epithelium and endothelium, forming a continuous zone of adhesion called the adhesion belt. In other tissues, such as  heart muscle, they appear as clusters, linking the cells to produce coordinated heart muscle contraction.
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