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Updated: May 24, 2026

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Published on: August 26, 2025
Acute gastrointestinal bleeding after percutaneous coronary intervention
Michael C Wallace1, Jamie Rankin, Geoffrey M Forbes
1Department of Gastroenterology and Hepatology, Royal Perth Hospital, Perth, WA 6001, Australia. michael.wallace2@health.wa.gov.au
Insights
Gastrointestinal bleeding is common after percutaneous coronary intervention. Managing this requires balancing bleeding control with preventing heart complications.
Area of Science:
- Cardiology
- Gastroenterology
Background:
- Gastrointestinal (GI) bleeding is a frequent complication following percutaneous coronary intervention (PCI).
- Advancements in PCI, including smaller sheath sizes and radial artery access, are shifting bleeding complications from access sites to the GI tract.
- Managing GI bleeding post-PCI necessitates a careful balance between hemostasis and preventing ischemic cardiac events.
Purpose of the Study:
- To provide essential knowledge for managing GI bleeding in patients undergoing PCI.
- To offer practical recommendations for clinicians facing this clinical challenge.
- To assist healthcare providers in managing this potentially life-threatening complication.
Main Methods:
- This is a review article.
- It synthesizes current knowledge on GI bleeding after PCI.
- It includes practical recommendations based on clinical practice.
Main Results:
- GI bleeding is an increasingly recognized complication of PCI.
- Effective management requires a multidisciplinary approach considering both cardiac and GI factors.
- Balancing anticoagulation/antiplatelet therapy with bleeding risk is crucial.
Conclusions:
- Clinicians must possess a dual understanding of cardiovascular and gastrointestinal conditions.
- A strategic approach is needed to manage GI bleeding post-PCI effectively.
- Recommendations are provided to aid clinicians in managing this serious complication.
Abstract:
Bleeding from the GI tract is a commonly encountered clinical problem after percutaneous coronary intervention. The GI tract is likely to become the most commonly encountered site of bleeding as cardiologists adopt smaller access sheath sizes, percutaneous closure devices and a radial artery approach, further reducing access-site bleeding. To appropriately manage gastrointestinal bleeding in this setting, the clinician must strike a balance between arresting hemorrhage and preventing ischemic coronary complications. To do so, an appreciation of both cardiovascular and gastrointestinal issues is required. This review aims to provide the required knowledge, as well as a series of recommendations from our practice, to assist in the management of this potentially fatal complication.
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