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The role of the MTHFR gene in migraine

Shani Stuart1, Hannah C Cox, Rod A Lea

  • 1Genomics Research Centre, Griffith Health Institute, Griffith University, Gold Coast Campus, Southport, QLD, Australia.

Headache
|March 2, 2012
PubMed

Insights

Researchers identified three methylenetetrahydrofolate reductase (MTHFR) gene variants associated with migraine susceptibility in a unique population. This finding reinforces the MTHFR gene's role in the complex neurological disorder, migraine.

Area of Science:

  • Neuroscience
  • Genetics
  • Vascular Biology

Background:

  • Migraine is a prevalent neurological disorder with diverse symptoms, including head pain, nausea, and photophobia.
  • Genetic factors, particularly those influencing vascular regulation, are implicated in migraine pathogenesis.
  • The methylenetetrahydrofolate reductase (MTHFR) gene is of significant interest, especially in migraine with aura, which has links to stroke.

Purpose of the Study:

  • To investigate the role of the methylenetetrahydrofolate reductase (MTHFR) gene in migraine.
  • To explore MTHFR genetic variants within a specific population isolate.
  • To identify potential genetic markers for migraine susceptibility.

Main Methods:

  • Analysis of MTHFR gene single nucleotide polymorphisms (SNPs) in the Norfolk Island population.
  • Utilizing a genetic isolate to enhance the study of specific genetic variants.
  • Investigating the association between identified MTHFR SNPs and migraine.

Main Results:

  • Three specific MTHFR single nucleotide polymorphisms (SNPs) were found to be associated with migraine in the study population.
  • These findings provide evidence supporting the involvement of MTHFR in migraine susceptibility.
  • The study highlights the utility of genetic isolates for investigating complex diseases.

Conclusions:

  • The methylenetetrahydrofolate reductase (MTHFR) gene plays a potential role in migraine susceptibility.
  • Further research is needed to build a comprehensive genetic profile for migraine.
  • Understanding the genetic underpinnings of migraine can lead to improved insights into its complex etiology.

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