[Prevention of pulmonary embolism after brain surgery with the use of local heparinization]

The authors describe briefly anticoagulation treatment of thrombosis of the lower extremity by heparin which developed on the third day after operation of a glioblastoma of the temporal lobe. An adequate therapeutic dose of heparin administered by infusion into the affected lower extremity was neutralized by an infusion of protamine into the upper extremity. Haematological examination revealed normal clotting in the systemic circulation. The method of local heparinization improved the clinical symptoms, pulmonary embolism did not develop and was there was no hemorrhage complication in the surgical field.