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Related Concept Videos

Pharmacodynamic Models: Linear Concentration–Effect Model01:15

Pharmacodynamic Models: Linear Concentration–Effect Model

The linear concentration–effect model, underpinned by the principle that pharmacological effect (E) is directly proportional to plasma drug concentration (C), emerges as a pivotal simplification of the Emax model for conditions where C is significantly less than EC50. This model portrays a linear trajectory of the concentration–effect relationship when drug levels are markedly below the EC50 threshold.Despite its inherent assumption of continuous effect augmentation with increasing drug...
Complexometric EDTA Titration Curves01:20

Complexometric EDTA Titration Curves

EDTA titration curves determine the free metal ion concentration. The titration curve represents the change in concentration of free metal ions (p function) as a function of the volume of EDTA added. This curve consists of three regions: before, at, and after equivalence points. Excess free metal ions are present before the equivalence point. Equal concentrations of metal ions and EDTA are present at the equivalence point. After the equivalence point, excess EDTA exists. This means slight...
EDTA: Auxiliary Complexing Reagents01:26

EDTA: Auxiliary Complexing Reagents

EDTA titrations are usually carried out in highly basic conditions, where the fully deprotonated form of EDTA, Y4−, actively complexes with the free metal ions in the solution. Several metal ions precipitate as hydrous oxide (hydroxides, oxides, or oxyhydroxides) under these conditions, lowering the concentration of free metal ions in the solution. For this reason, auxiliary complexing agents or ligands such as ammonia, tartrate, citrate, or triethanolamine are used in EDTA titrations to...
Ion-Exchange Chromatography01:09

Ion-Exchange Chromatography

Ion-exchange chromatography, or IEC, is a technique for separating ions based on their affinity for the stationary phase. The stationary phase is a cross-linked polymer resin with covalently attached ionic functional groups. The functional groups can be either positively charged (cation exchangers) or negatively charged (anion exchangers). A cation exchanger consists of a polymeric anion and active cations, while an anion exchanger is a polymeric cation with active anions. The choice of...
EDTA: Direct, Back-, and Displacement Titration01:30

EDTA: Direct, Back-, and Displacement Titration

The EDTA titration types for metal ion analysis include direct titration, back-titration, and replacement titration.
Direct titration involves buffering the metal ion solution to the desired pH and directly titrating with standard EDTA until the endpoint. The optimum pH ensures a large conditional formation constant of metal−EDTA and visibility of the free indicator color in the solution. In addition, auxiliary complexing reagents are used to prevent the precipitation of metal hydroxides and...
EDTA: Indirect and Alkalimetric Titration01:23

EDTA: Indirect and Alkalimetric Titration

Unlike direct titration, back-titration, and displacement titration, indirect titration is an EDTA titration method for quantifying anions. In the indirect titration method, anions are precipitated as their insoluble salts with excess metal ions. The filtrate containing the excess metal ions is directly titrated with standard EDTA until the endpoint is achieved. Another approach involves extracting the metal ion and back-titrating with standard EDTA to obtain the endpoint. In this way, the...

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Understanding Dissolved Organic Matter Biogeochemistry Through In Situ Nutrient Manipulations in Stream Ecosystems
09:38

Understanding Dissolved Organic Matter Biogeochemistry Through In Situ Nutrient Manipulations in Stream Ecosystems

Published on: October 29, 2016

Predicting EDC concentrations in a river mixing zone.

Sheree A Pagsuyoin1, Wu-Seng Lung, Lisa M Colosi

  • 1Department of Civil and Environmental Engineering, University of Virginia, Charlottesville, VA 22904-4742, United States.

Chemosphere
|March 2, 2012
PubMed
Summary

This study introduces a new method to map endocrine disrupting chemicals (EDCs) in rivers near wastewater plants. The model predicts EDC levels, aiding water quality management and revealing an in-stream attenuation rate for 17β-estradiol.

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Clean Sampling and Analysis of River and Estuarine Waters for Trace Metal Studies

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Area of Science:

  • Environmental Chemistry
  • Water Quality Management
  • Environmental Modeling

Background:

  • Endocrine disrupting chemicals (EDCs) from wastewater treatment plants (WWTPs) pose risks to river ecosystems.
  • Understanding EDC fate and transport in river mixing zones is crucial for environmental protection.

Purpose of the Study:

  • To develop and validate a methodology for quantifying the spatial distribution of EDCs in river mixing zones.
  • To demonstrate the application of this methodology for water quality management.

Main Methods:

  • A two-dimensional steady-state analytical model simulating ambient turbulence was employed.
  • The model was calibrated using field measurements of electrical conductivity (a conservative substance).
  • The calibrated model predicted aqueous-phase EDC concentrations within a WWTP mixing zone.

Main Results:

  • The methodology successfully quantified the spatial distribution of EDCs.
  • A lumped in-stream attenuation rate constant (k(d)=3 d⁻¹) for 17β-estradiol was determined under natural conditions.
  • The determined rate constant aligns with previous bench-scale removal experiment findings.

Conclusions:

  • The presented modeling framework is effective for assessing EDC spatial distribution in river mixing zones.
  • The methodology provides valuable data for water quality management and risk assessment of EDCs.
  • The determined attenuation rate offers insights into the combined removal processes affecting 17β-estradiol in rivers.