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A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks
Published on: June 26, 2020
Hepatitis E virus infection in HIV-infected persons
Nancy F Crum-Cianflone1, Jennifer Curry, Jan Drobeniuc
1Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA.
Emerging Infectious Diseases
|March 2, 2012
Summary
Hepatitis E virus (HEV) may cause hepatitis in individuals with HIV. Researchers found evidence of HEV infection in a small percentage of HIV-positive military beneficiaries, suggesting a potential link.
Area of Science:
- Hepatology
- Infectious Diseases
- Virology
- Immunocompromised Hosts
Background:
- Hepatitis E virus (HEV) is a significant cause of acute hepatitis globally.
- Human immunodeficiency virus (HIV) infection can alter immune responses and susceptibility to other infections.
- The role of HEV as a cause of hepatitis in HIV-infected populations remains under-explored.
Purpose of the Study:
- To investigate the potential association between hepatitis E virus (HEV) infection and hepatitis in individuals living with HIV.
- To determine the prevalence of HEV infection among a cohort of HIV-infected US military beneficiaries.
Main Methods:
- Retrospective analysis of data from 194 HIV-infected US military beneficiaries spanning 1985-2009.
- Serological testing to detect evidence of acute or prior hepatitis E virus (HEV) infection.
Main Results:
- Evidence of acute HEV infection was identified in 7 (4%) of the 194 HIV-infected individuals.
- Evidence of prior HEV infection was detected in 5 (3%) of the cohort.
- These findings suggest HEV is a potential cause of hepatitis in this population.
Conclusions:
- Hepatitis E virus (HEV) infection should be considered in the differential diagnosis of hepatitis among HIV-infected persons.
- Further research is warranted to understand the clinical implications and management of HEV in immunocompromised individuals.
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