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Disseminated kidney tuberculosis complicating autosomal dominant polycystic kidney disease: a case report

Hideki Takeshita1, Morimasa Amemiya, Koji Chiba

  • 1Department of Urology, Saitama Red Cross Hospital, Saitama, Japan. take_uro@ybb.ne.jp

Clinical Nephrology
|March 2, 2012
PubMed

Insights

Tuberculosis (TB) in autosomal dominant polycystic kidney disease (ADPKD) patients is rare and challenging to treat due to cyst penetration issues. Early diagnosis and surgical intervention are crucial for better outcomes in kidney TB within ADPKD.

Area of Science:

  • Nephrology
  • Infectious Diseases
  • Urology

Background:

  • Autosomal dominant polycystic kidney disease (ADPKD) presents unique challenges for managing infections.
  • Mycobacterium tuberculosis (TB) infections in ADPKD patients are uncommon and difficult to diagnose and treat.
  • Antibiotic penetration into infected cysts in ADPKD is often limited, complicating treatment strategies.

Observation:

  • A case report of a 43-year-old Japanese male with disseminated urogenital tuberculosis (TB) and ADPKD without HIV infection is presented.
  • The patient experienced delayed diagnosis and ineffective anti-TB chemotherapy, leading to disease progression.
  • The patient ultimately required bilateral nephrectomy, which resulted in postoperative complications.

Findings:

  • Kidney tuberculosis (TB) should be considered a significant cause of renal infection in patients with ADPKD.
  • Delayed diagnosis and suboptimal anti-TB chemotherapy exacerbated the patient's condition.
  • Surgical intervention, such as bilateral nephrectomy, may be necessary but carries risks of complications.

Implications:

  • Early recognition and diagnosis of kidney TB in ADPKD patients are critical.
  • Prompt and appropriate treatment, including surgical options, is essential to prevent disease deterioration.
  • This case highlights the need for increased awareness and tailored management approaches for TB in ADPKD patients.

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