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Network Analysis of Foramen Ovale Electrode Recordings in Drug-resistant Temporal Lobe Epilepsy Patients
Published on: December 18, 2016
Mismatch negativity for speech sounds in temporal lobe epilepsy.
Keiko Hara1, Katsuya Ohta, Miho Miyajima
1Department of Life Sciences and Biofunctional Informatics, Graduate School of Health Care Sciences, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo, Japan. hrkeiko.bi@tmd.ac.jp
Epilepsy & Behavior : E&B
|March 2, 2012
Summary
Temporal lobe epilepsy (TLE) reduces auditory sensory memory, specifically the mismatch positivity (MMP) response, while leaving the mismatch negativity (MMN) unchanged. This suggests TLE differentially affects brain sources involved in auditory change detection.
Area of Science:
- Neuroscience
- Auditory Neuroscience
- Epilepsy Research
Background:
- Mismatch negativity (MMN) is an electroencephalography (EEG) marker for pre-attentive auditory sensory memory.
- Temporal lobe epilepsy (TLE) is a neurological disorder affecting brain function.
Purpose of the Study:
- To investigate auditory sensory memory in TLE patients using the MMN and mismatch positivity (MMP) responses.
- To determine if TLE differentially affects the brain sources generating MMN and MMP.
Main Methods:
- Used a phonetic oddball paradigm with alternating vowels ('a' and 'o') in 26 TLE patients and 26 controls.
- Recorded EEG responses at fronto-central (MMN) and mastoid (MMP) sites.
- Analyzed average waveforms for standard and deviant trials.
Main Results:
- MMP response at bilateral mastoid sites was significantly reduced in TLE patients compared to controls.
- MMN response at fronto-central sites showed no significant change between TLE patients and controls.
- Findings suggest separable neural sources for MMN and MMP.
Conclusions:
- TLE differentially impacts brain regions involved in auditory change detection.
- The reduced MMP indicates impaired pre-attentive auditory processing in TLE.
- MMN and MMP may originate from distinct neural generators, differentially affected by TLE.
