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Updated: May 24, 2026

Modeling Stroke in Mice: Permanent Coagulation of the Distal Middle Cerebral Artery
Published on: July 31, 2014
Caudate infarcts and hemorrhages
Michele Pellizzaro Venti1, Maurizio Paciaroni, Valeria Caso
1Stroke Unit and Division of Internal and Cardiovascular Medicine, University of Perugia, Perugia, Italy. michelepellizzaroventi@live.it
Insights
Strokes affecting the caudate nucleus (CN), whether hemorrhagic or ischemic, can cause various neurological symptoms. Fortunately, research indicates that vascular pathologies of the CN generally have favorable outcomes.
Area of Science:
- Neuroscience
- Neurology
- Vascular Neurology
Background:
- The caudate nucleus (CN) is a key brain structure with distinct anatomical parts: head, body, and tail.
- The head of the CN plays a role in forming the lateral ventricle's frontal horn and is situated near the thalamus and corpus callosum.
- CN strokes are categorized as either hemorrhagic or ischemic.
Purpose of the Study:
- To summarize the anatomical location and clinical manifestations of caudate nucleus strokes.
- To review the typical clinical presentations and outcomes associated with CN vascular pathologies.
Main Methods:
- Review of existing literature on caudate nucleus vascular pathologies.
- Analysis of clinical features associated with both hemorrhagic and ischemic CN strokes.
- Examination of reported patient outcomes for CN stroke cases.
Main Results:
- Caudate nucleus hemorrhage can present with symptoms similar to subarachnoid hemorrhage.
- Both ischemic and hemorrhagic CN strokes may lead to behavioral changes, dysarthria, movement disorders, language deficits, and memory loss.
- Studies examining vascular CN pathologies predominantly report good patient outcomes.
Conclusions:
- Caudate nucleus strokes present with a range of neurological deficits.
- Despite diverse clinical presentations, vascular pathologies of the caudate nucleus are often associated with positive prognoses.
Abstract:
The caudate nucleus (CN) is composed of a head, body and tail. The head of the CN contributes to forming the floor of the lateral ventricle frontal horn. Moreover, the head, which is medially separated by the septum pellucidum extends beyond the anterior part of the thalamus, stroking the telencephalic cortex. The superior part of the head is covered by the knee of the corpus callosum, while the inferior part is below the thalamus and lenticular nucleus, which delimits the internal capsule. CN strokes are classified into hemorrhagic and ischemic. The clinical presentation of CN hemorrhage is often characterized by a clinical presentation mimicking subarachnoid hemorrhage, while clinical features of both ischemic and hemorrhagic strokes included behavioral abnormalities dysarthria, movement disorders, language disturbances and memory loss. Most studies to date that have examined vascular CN pathologies have evidenced good outcomes.
Related Concept Videos
Hemorrhagic Stroke l: Introduction
Hemorrhagic Stroke ll: Pathophysiology
Ischemic Stroke ll: Pathophysiology
Stroke: Introduction and Types
Transient Ischemic Attack l: Introduction
Ischemic Stroke l: Introduction

