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Related Concept Videos

Immunodeficiency Diseases01:25

Immunodeficiency Diseases

Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency disorders...
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin create...
Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...

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Related Experiment Video

Updated: May 24, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering
12:23

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

Skin problems in immunodeficient patients.

Peter H Itin1, Manuel Battegay

  • 1Dermatology, University Hospital Basel, Petersgraben 4, Basel, Switzerland. itinp@uhbs.ch

Current Problems in Dermatology
|March 2, 2012
PubMed
Summary
This summary is machine-generated.

The skin

Related Experiment Videos

Last Updated: May 24, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering
12:23

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

Area of Science:

  • Immunology
  • Dermatology
  • Microbiology

Background:

  • The skin's epidermis provides critical defense against mechanical, chemical, and microbial threats.
  • Immunosuppression compromises skin integrity, leading to mucocutaneous complications.
  • Commensal microbes and antimicrobial peptides normally protect against pathogens.

Purpose of the Study:

  • To review the pathophysiology of skin protection.
  • To describe mucocutaneous problems in immunosuppressed patients.
  • To highlight the importance of biopsies in diagnosing infections in these patients.

Main Methods:

  • Literature review of skin's protective functions.
  • Analysis of mucocutaneous manifestations in immunosuppression.
  • Discussion of diagnostic approaches including histology and microbiology.

Main Results:

  • Immunodeficiency, from various causes, increases susceptibility to infections.
  • Oncogenic viruses can cause long-term skin cancers like Kaposi sarcoma and Merkel cell tumors.
  • Specific markers like oral hairy leukoplakia indicate immunosuppression.

Conclusions:

  • Immunosuppressed patients present with atypical mucocutaneous infections.
  • Liberal biopsy with histology and cultures is crucial for diagnosis.
  • Understanding skin's role in immunity is vital for managing immunosuppressed individuals.