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Aortic Regurgitation II: Clinical Features and Diagnostic Tests01:22

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Exercise Test for Evaluation of the Functional Efficacy of the Pig Cardiovascular System
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Aortic function: from the research laboratory to the clinic.

Konstantinos Dean Boudoulas1, Charalambos Vlachopoulos, Subha V Raman

  • 1Division of Cardiovascular Medicine, The Ohio State University, 473 W. 12th Avenue, Columbus, OH 43210, USA. kdboudoulas@osumc.edu

Cardiology
|March 2, 2012
PubMed
Summary

Clinical investigators are transitioning aortic function research from the lab to patient care. Future collaboration will integrate molecular insights into clinical practice, potentially preventing aortic dysfunction.

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Area of Science:

  • Cardiovascular Research
  • Translational Medicine
  • Aortic Physiology

Background:

  • Historically, aortic function research was primarily laboratory-based.
  • Clinical application of aortic function indices like pulse wave velocity was limited.
  • The transition from basic science to clinical practice was essential.

Purpose of the Study:

  • To highlight the crucial role of clinical investigators in translating aortic function research.
  • To emphasize the future integration of aortic function assessment into routine clinical practice.
  • To advocate for enhanced collaboration between basic and clinical scientists.

Main Methods:

  • Review of historical research trends in aortic function.
  • Analysis of the progression of aortic function indices from research to clinical use.
  • Discussion of future research directions and clinical applications.

Main Results:

  • Pioneering research defined fundamental aortic function mechanisms.
  • Clinical investigators adapted and introduced practical aortic function measurements.
  • Aortic function assessment is poised for widespread clinical adoption.

Conclusions:

  • Clinical investigators are key to implementing aortic function measurements in daily practice.
  • Future advancements require collaboration to understand collagen and elastin dynamics.
  • This integration may prevent or delay age-related and disease-related aortic dysfunction.