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Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity

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Transient coordinated activity within the developing brain's default network.

Vera Nenadovic, Luis Garcia Dominguez, Marc D Lewis

Cognitive Neurodynamics

|March 2, 2012

Summary

As children mature, functional coordination within the brain's default network increases. This study shows more stable synchronization patterns in older children, reflecting developmental changes in introspection.

Keywords:

Default network Electroencephalography Fluctuations Instantaneous phase Synchronization

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Area of Science:

Neuroscience
Developmental Neuroscience
Cognitive Neuroscience

Background:

The brain's default network is active during introspective thought.
Functional coordination between neuronal groups is crucial for information processing.
Introspection develops with age in children.

Purpose of the Study:

To investigate the developmental changes in functional coordination within the default network in children.
To examine how age influences the spatio-temporal patterns of phase synchrony in default network regions.

Main Methods:

Used electroencephalography (EEG) recordings in 17 children (11 months to 17 years).
Recorded brain activity during quiet rest with eyes closed.
Analyzed phase synchrony patterns and their variability across default network regions and compared them to other brain areas.

Main Results:

Observed lower variability in spatio-temporal phase synchrony patterns within the default network in older children compared to younger children.
Demonstrated increased functional coordination among default network regions with increasing age.

Conclusions:

Functional coordination within the brain's default network strengthens during childhood development.
Maturation of introspection is associated with increased functional integration in the default network.