Related Experiment Video
Updated: May 24, 2026

Immunofluorescent Labeling in Nasal Mucosa Tissue Sections of Allergic Rhinitis Rats via Multicolor Immunoassay
Published on: September 22, 2023
Predisposing factors associated with chronic and recurrent rhinosinusitis in childhood
Sun-Hee Choi1, Man-Yong Han, Young-Min Ahn
1Department of Pediatrics, College of Medicine, Kyung Hee University, Seoul, Korea.
Insights
Allergic diseases like atopy and asthma are linked to chronic rhinosinusitis (RS) in children. This study identified predisposing factors for chronic and recurrent RS in pediatric patients.
Area of Science:
- Pediatric Otolaryngology
- Allergy and Immunology
- Epidemiology
Background:
- Chronic and recurrent rhinosinusitis (RS) are multifactorial conditions.
- Allergic diseases are implicated in the pathogenesis of RS.
- Predisposing factors for chronic and recurrent RS remain largely uncharacterized.
Purpose of the Study:
- To investigate potential predisposing factors associated with chronic and recurrent rhinosinusitis (RS).
- To evaluate the role of allergic diseases in the development of chronic and recurrent RS in children.
Main Methods:
- Prospective study involving pediatric patients diagnosed with RS.
- Data collected from six tertiary referral hospitals in Korea.
- Demographic and clinical data were analyzed to identify associations.
Main Results:
- 296 pediatric patients with RS were recruited.
- Chronic RS (18.9%) and recurrent RS (11.5%) were identified.
- Higher prevalences of allergic rhinitis, atopy, and asthma were observed in chronic/recurrent RS patients compared to acute/subacute RS patients.
Conclusions:
- Atopy is significantly associated with chronic and recurrent RS in pediatric patients.
- The findings suggest a potential causal link between atopy and the development of chronic/recurrent RS.
Purpose:
There is currently no information regarding predisposing factors for chronic and recurrent rhinosinusitis (RS), although these are considered to be multifactorial in origin, and allergic diseases contribute to their pathogenesis. We evaluated the predisposing factors that may be associated with chronic and recurrent RS.
Methods:
In this prospective study, we examined patients with RS younger than 13 years of age, diagnosed with RS at six tertiary referral hospitals in Korea between October and December, 2006. Demographic and clinical data related to RS were recorded and analyzed.
Results:
In total, 296 patients were recruited. Acute RS was the most frequent type: 56.4% of the patients had acute RS. The prevalences of other types of RS, in descending order, were chronic RS (18.9%), subacute RS (13.2%), and recurrent RS (11.5%). Factors associated with recurrent RS were similar to those of chronic RS. Patients with chronic and recurrent RS were significantly older than those with acute and subacute RS. The prevalences of allergic rhinitis, atopy, and asthma were significantly higher in patients with chronic and recurrent RS than those with acute and subacute RS.
Conclusions:
An association between atopy and chronic/recurrent RS, compared to acute and subacute RS, suggests a possible causal link.
Related Concept Videos
Asthma I: Introduction
Chronic Pharyngitis
Etiology
It often arises from persistent viral or bacterial infections affecting sinuses and tonsils.
Additional contributing factors include inadequate dental hygiene, mouth breathing, recurring tonsillitis, allergic rhinitis, laryngopharyngeal reflux, and exposure to smoke, chemicals, and other environmental pollutants. Allergic reactions to pollen, mold, and pet dander, chronic cough, excessive voice usage,...
Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features
Asthma-I: Introduction
Microbiota of the Respiratory Tract
Common Respiratory Disorders
Upper respiratory disorders impact the airways above the vocal cords, encompassing areas like the nose, sinuses, and throat. Various conditions fall under this category, including the common cold and allergic rhinitis. These disorders can stem from several causes,...

