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Related Experiment Videos

Growth factor expression after stroke.

S P Finklestein1, C G Caday, M Kano

  • 1CNS Growth Factor Research Laboratory, Massachusetts General Hospital, Boston 02114.

Stroke
|November 1, 1990
PubMed
Summary
This summary is machine-generated.

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Basic fibroblast growth factor (bFGF) levels significantly increase after stroke in rats, suggesting a role in brain repair. This finding highlights bFGF

Area of Science:

  • Neuroscience
  • Cell Biology
  • Biochemistry

Background:

  • Fibroblast growth factors (FGFs) are critical polypeptides with significant trophic effects on central nervous system cells.
  • Both acidic and basic forms of FGF are present in the mammalian brain.
  • Understanding FGF expression post-brain injury is crucial for developing therapeutic strategies.

Purpose of the Study:

  • To investigate the expression patterns of acidic and basic fibroblast growth factors (FGFs) in the rat brain following focal cerebral infarction.
  • To determine the temporal dynamics of FGF expression in the peri-infarct tissue.

Main Methods:

  • Induction of focal cerebral infarction in the lateral cerebral cortex of mature rats.
  • Quantification of acidic and basic FGF levels in the surrounding brain tissue at various time points post-stroke (3 weeks and 2 months).

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Main Results:

  • A twofold to threefold increase in overall FGF levels was observed in the tissue surrounding infarcts within 3 weeks post-stroke.
  • This elevated FGF expression persisted for at least 2 months.
  • The increase was primarily attributed to elevated levels of basic FGF, while acidic FGF levels remained largely unchanged.

Conclusions:

  • Basic fibroblast growth factor (bFGF) expression is significantly upregulated following ischemic stroke in the rat brain.
  • The sustained increase in bFGF suggests its potential involvement in the neuroprotective and regenerative processes after stroke.
  • bFGF's known gliotrophic, angiogenic, and neuronotrophic properties indicate its critical role in wound healing and functional recovery post-stroke.