[Cardioprotective properties of sevoflurane in coronary bypass surgery with extracorporeal circulation]

The aim of the study is to investigate cardioprotective properties of sevoflurne during coronary bypass surgery with extracorporeal circulation.

60 patients with coronary heart disease (left ventricular ejection fraction 61,3+1,0%) underwent surgery with extracorporeal circulation. Inhalation anesthesia with Sevoflurane and TIVA were performed. Hemodynamic, troponin level, KFK, protein of heart shock in plasma (PHS 70) and PHS in myocard were monitored.

patients who were administrated with Sevoflurane had lower level of troponin than patients of second group. In postperfusion period the amount of PHS 70 in myocard increased in 1.6 times than in preperfusion period in comparison to TIVA method this figure did not change. There was negative correlation in level of PHS 70 in plasma and troponin in first day after the operation (r = -0,61 p < 0,05) and second day (r = - 0,76, p < 0,05). In conclusion Sevoflurane had affected hemodynamic less than TIVA. Increased level of PHS has cardioprotective effects.