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Published on: October 17, 2025
Multiple relapses in extramedullary localization of acute lymphoblastic leukemia
1Department of Radiology, Medical School of Karadeniz Technical University, Farabi Hospital, Trabzon, Turkey. polatkosucu@hotmail.com
Bratislavske Lekarske Listy
|March 3, 2012
Summary
Extramedullary relapses of acute lymphoblastic leukemia (ALL) are uncommon, typically affecting the central nervous system or testes. This case highlights a young adult with ALL experiencing rare, multiple extramedullary relapses in diverse organs.
Area of Science:
- Hematology
- Oncology
- Pediatric Oncology
Background:
- Acute lymphoblastic leukemia (ALL) is a common childhood cancer.
- Extramedullary relapses, occurring outside the bone marrow, are infrequent in ALL.
- Common sites for extramedullary relapse include the central nervous system and testes.
Observation:
- A case study of a 25-year-old male patient with ALL is presented.
- The patient experienced multiple extramedullary relapses.
- Relapses occurred in unusual locations including the testes, gallbladder, breast, parotid gland, and eye.
Findings:
- This case demonstrates a rare pattern of widespread extramedullary disease in ALL.
- The patient presented with relapses in multiple, non-contiguous organs.
- The diverse sites of relapse challenge typical patterns observed in pediatric and young adult ALL.
Implications:
- Highlights the need for vigilance in monitoring for extramedullary disease in ALL patients.
- Suggests that ALL can disseminate to a wider range of organs than commonly recognized.
- May inform diagnostic and treatment strategies for patients with refractory or relapsed ALL.
