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Related Concept Videos

Development of Immunocompetence01:22

Development of Immunocompetence

The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

Overview
Immunodeficiency Diseases01:25

Immunodeficiency Diseases

Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency disorders...

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Multiplexed Fluorescent Immunohistochemical Staining of Four Endometrial Immune Cell Types in Recurrent Miscarriage
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Published on: August 4, 2021

Multiple pregnancy failures: an immunological paradigm.

Leif Matthiesen1, Satyan Kalkunte, Surendra Sharma

  • 1Department Obstetrics and Gynecology, Helsingborg Hospital, Affiliated Lunds University, Sweden. leif.matthiesen@skane.se

American Journal of Reproductive Immunology (New York, N.Y. : 1989)
|March 3, 2012
PubMed
Summary
This summary is machine-generated.

Recurrent spontaneous abortion (RSA) affects 1% of pregnancies, often with unexplained causes. This review explores immune factors and therapies, including heparin and growth factors, to improve outcomes for recurrent pregnancy loss.

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Published on: October 25, 2024

Area of Science:

  • Reproductive Immunology
  • Obstetrics and Gynecology

Background:

  • Recurrent spontaneous abortion (RSA) impacts ~1% of pregnancies, with 50% of cases remaining unexplained.
  • Immune dysregulation and placental vascular issues are increasingly implicated in pregnancy complications like RSA.
  • Current RSA management guidelines lack consensus due to suboptimal study designs.

Purpose of the Study:

  • To review evidence-based immunologic causes of RSA.
  • To discuss immune-regulatory therapies for patients experiencing recurrent pregnancy loss.
  • To highlight potential treatments for unexplained recurrent spontaneous abortion.

Main Methods:

  • Evidence-based literature review focusing on immunologic factors in RSA.
  • Analysis of existing research on immune-regulatory therapies for recurrent pregnancy loss.
  • Examination of data supporting specific therapeutic interventions.

Main Results:

  • Immune pathways play a significant role in the pathophysiology of RSA.
  • Low molecular weight heparin shows potential as a protective therapy for RSA.
  • Novel agents like GM-CSF, regulatory T cells, hCG, and M-CSF/IL-10 may offer new treatment avenues.

Conclusions:

  • Understanding immune mechanisms is crucial for managing unexplained RSA.
  • Revalidation of heparin and exploration of novel immunomodulatory agents offer hope for recurrent pregnancy loss.
  • Integrated therapeutic approaches may improve success rates for couples with multiple pregnancy losses.