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Treslin, DUE-B, and GEMC1 cannot complement Sld3 mutants in fission yeast

Zhuo Wang1, Elaine Kim, Michael Leffak

  • 1Department of Biochemistry and Molecular Biology, Wright State University Boonshoft School of Medicine, Dayton, OH 45435, USA.

FEMS Yeast Research
|March 3, 2012
PubMed
Summary

Researchers investigated if metazoan proteins Treslin/Ticrr, GEMC1, and DUE-B could functionally replace yeast Sld3 in DNA replication. These proteins did not rescue growth defects in yeast mutants, suggesting evolutionary divergence in helicase activation mechanisms.

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