[The effect of mepacrine and propranolol on lipid level in the alveolar surfactant during anaphylactic shock]

It is shown that the development of anaphylactoid shock in rats is connected with a decrease of the surface activity of alveolar surfactant and liberation of arachidonic acid from pulmonary surfactant phospholipids. Preventive injection of lipomodulators--A2 phospholipase inhibitor (mepacrine) or triglycecolipase inhibitor (propranolol)--to animals normalizes the level of lipids in the surfactant and blocks liberation of arachidonate and palmitate from surfactant phospholipids in an anaphylactoid shock.