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Published on: October 9, 2018
Intrauterine transfusion for parvovirus B19 infection: long-term neurodevelopmental outcome
Eveline P De Jong1, Irene T Lindenburg, Jeanine M van Klink
1Department of Pediatrics, Juliana Children's Hospital, HAGA Hospital, The Hague, The Netherlands.
Objective:
To evaluate long-term neurodevelopmental outcome of children treated with intrauterine transfusions for fetal anemia because of parvovirus B19 infection.
Study Design:
Children treated with intrauterine transfusions for fetal anemia because of parvovirus B19 infection underwent standardized age-appropriate neurodevelopmental testing. Main outcome was the incidence of neurodevelopmental impairment.
Results:
Twenty-eight children were evaluated at a median age of 5 years (range, 1.5-13 years). Neurodevelopmental impairment was diagnosed in 3 of 28 (11%) children, including 1 child with combined cerebral palsy and severe developmental delay and 2 children with isolated severe developmental delay.
Conclusion:
Neurodevelopmental impairment in children treated with intrauterine transfusion for parvovirus B19 infection is increased compared with the general population. Large long-term follow-up studies are required to determine potential risk factors.
