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A Patient-Derived Xenograft Model for Venous Malformation
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Published on: June 15, 2020

An aetiological & clinicopathological study on cutaneous vasculitis.

Pooja Khetan1, Gomathy Sethuraman, Binod K Khaitan

  • 1Department of Dermatology & Venereology, All India Institute of Medical Sciences, New Delhi, India.

The Indian Journal of Medical Research
|March 3, 2012
PubMed
Summary

This study found hypersensitivity vasculitis and Henoch Schonlein purpura were common in cutaneous vasculitis. Most cases were idiopathic, with small vessel vasculitis being the most frequent histological pattern.

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A Methodological Approach to Non-invasive Assessments of Vascular Function and Morphology
09:33

A Methodological Approach to Non-invasive Assessments of Vascular Function and Morphology

Published on: February 7, 2015

Area of Science:

  • Dermatology
  • Pathology
  • Immunology

Background:

  • Cutaneous vasculitis presents with diverse clinical features and can be idiopathic or linked to infections, drugs, or connective tissue disorders.
  • Both small vessel vasculitis (SVV) and medium vessel vasculitis (MVV) affect the skin, often with overlapping clinical and histopathological characteristics.
  • Histopathological findings do not always correlate with clinical presentation in cutaneous vasculitis.

Purpose of the Study:

  • To investigate the etiological factors contributing to cutaneous vasculitis.
  • To analyze the clinicopathological associations in patients diagnosed with cutaneous vasculitis.
  • To understand the prevalence of different vasculitis types and their systemic involvement.

Main Methods:

  • A cross-sectional study involving 61 patients with biopsy-proven cutaneous vasculitis.
  • Detailed patient history and clinical examinations were conducted.
  • Two skin biopsies per patient were analyzed using routine histopathology and direct immunofluorescence.

Main Results:

  • Hypersensitivity vasculitis (37.7%) and Henoch Schonlein purpura (26.2%) were the most common forms.
  • Systemic involvement was observed in 52.45% of patients; drugs, infections, and connective tissue disorders were identified as potential causes.
  • Small vessel vasculitis (SVV) was the predominant histological pattern, observed in most patients, and direct immunofluorescence was positive in 62% of cases.

Conclusions:

  • The majority of cutaneous vasculitis cases in this cohort were idiopathic.
  • Small vessel vasculitis (SVV) was the most common histological finding.
  • No significant association was found between drug intake and tissue eosinophilia, or between histological severity and clinical presentation; IgA deposits were not specific to Henoch Schonlein purpura.