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[Selective screening for hypercholesterolemia. Results from a screening model in general practice].

E Agner1, T E Christensen, M S Mahnfeldt

  • 1Den Københavnske Kolesterolgruppe.

Ugeskrift for Laeger
|November 5, 1990
PubMed
Summary

Selective cholesterol screening in middle-aged men can identify high-risk individuals for coronary heart disease. Early detection and intervention, including lifestyle changes and medication, are crucial for reducing cardiovascular risk.

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Area of Science:

  • Cardiology
  • Preventive Medicine
  • Public Health

Context:

  • Coronary heart disease (CHD) risk is a significant public health concern, particularly in middle-aged men.
  • Current cholesterol intervention limits vary internationally, with Denmark having higher thresholds.
  • Widespread cholesterol screening is costly and may not be efficient for all demographics.

Purpose:

  • To describe and evaluate a model for selective cholesterol screening in high-risk groups within general practice settings.
  • To assess the prevalence of hypercholesterolaemia and other cardiovascular risk factors in a targeted population.

Summary:

  • A selective screening model targeted men aged 45-59 years in 20 general practices, measuring cholesterol, blood pressure, and tobacco consumption.
  • 41% of invitees participated; 29% exceeded the Danish cholesterol limit (≥7.0 mmol/l), and 44% exceeded the Western European limit (≥6.5 mmol/l).

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  • Severe hypercholesterolaemia (≥9.0 mmol/l) was found in 5% of participants, with an average of two such cases per practice. 28% had multiple risk factors.

    • Impact:

    • This selective screening approach facilitates immediate risk assessment and intervention commencement by general practitioners.
    • Identifies a substantial proportion of middle-aged men with elevated cholesterol and multiple cardiovascular risk factors requiring management.
    • Provides a cost-effective strategy for targeting interventions to individuals most likely to benefit, potentially reducing CHD incidence.